Assessment of Observations with GPS and GPS/GLONASS Satellites in rapid static mode for Precise Point Positioning

The use of Global Navigation Satellite Systems (GNSS) has become a common way of determining planimetric and vertical coordinates used in geodesy, engineering surveying, and related disciplines. The GNSS observation can be achieved using the static baseline, real Time kinematics (RTK) or the continuously operating reference system (CORS). The three are good methods of positioning that gives good and accurate coordinates. The static mode of observation considered by some researchers as the best in determining position of points at a good accuracy is used in this research in addition to its convenience. The satellites are tracked as standalone Global Positioning System (GPS) satellite and as GPS and Global Navgation Satellite System (GLONASS) combined. A ground surveying method using total station is also employed to run traverse and leveling on the same points for the purpose of comparison of the results. The GNSS observations were accomplished using Hi target V30 while traversing and leveling were carried out using a South NTS 352 total station instrument. The observations were done on the same points with the two instruments which give three sets of data comprising of planimetric and vertical coordinates. Discrepancies among the data set were obtained and subjected to statistical test. The result shows some discrepancies among the data sets, the statistical test indicated a significant difference among the methods and data of the three methods on the planimetric coordinates. However in the vertical coordinates, the methods show no significant difference but the vertical coordinate showed a significant difference among the three data sets

Towards a Deadline-Based Simulation Experimentation Framework Using Micro-Services Auto-Scaling Approach

There is growing number of research efforts in developing auto-scaling algorithms and tools for cloud resources. Traditional performance metrics such as CPU, memory and bandwidth usage for scaling up or down resources are not sufficient for all applications. For example, modeling and simulation experimentation is usually expected to yield results within a specific timeframe. In order to achieve this, often the quality of experiments is compromised either by restricting the parameter space to be explored or by limiting the number of replications required to give statistical confidence. In this paper, we present early stages of a deadline-based simulation experimentation framework using a micro-services auto-scaling approach. A case study of an agent-based simulation of a population physical activity behavior is used to demonstrate our framework

Optimum Design of Doherty RFPA for Mobile WiMAX Base Stations

YesRF power amplifiers in mobile WiMAX transceivers operate in an inherently nonlinear manner. It is possible to amplify the signal in the linear region, and avoid distortion, using output power back-off; however, this approach may suffer significant reduction in efficiency and power output. This paper investigates the use of Doherty techniques instead of back-off, to simultaneously achieve good efficiency and acceptable linearity. A 3.5 GHz Doherty RFPA has been designed and optimized using a large signal model simulation of the active device, and performance analysis under different drive levels. However, the Doherty EVM is generally poor for mobile WiMAX. Linearity may be improved by further digital pre-distortion, and a simple pre-distortion method using forward and reverse AM-AM and AM-PM modeling. Measurements on the realized amplifier show that this approach satisfies the EVM requirements for WiMAX base stations. It exhibits a PAE over 60%, and increases the maximum linear output power to 43 dBm, whilst improving the EVM

Explanation of DC/RF Loci for Active Patch Antennas

YesA characteristic loop locus of dc power versus RF output power was observed as the frequency was varied around the optimum point of an operational active antenna. A new technique was introduced into the simulation, plotting the dependence of parameters such as supply current, efficiency or output power on internal impedance as seen by the naked transistor. It is now clear that the loop was formed as a consequence of the interaction of the transistor packaging elements with the patch impedances

Innovations in Simulation: Experiences with Cloud-based Simulation Experimentation

The amount of simulation experimentation that can be performed in a project can be restricted by time, especially if a model takes a long time to simulate and many replications are required. Cloud Computing presents an attractive proposition to speeding up, or extending, simulation experimentation as computing resources can be hired on demand rather than having to invest in costly infrastructure. However, it is not common practice for simulation users to take advantage of this and, arguably, rather than speeding up simulation experimentation users tend to make compromises by using unnecessary model simplification techniques. This may be due to a lack of awareness of what Cloud Computing can offer. Based on several years’ experience of innovation in this area, this article presents our experiences in developing Cloud Computing applications for simulation experimentation and discusses what future innovations might be created for the widespread benefit of our simulation community

Large-scale radio propagation path loss measurements and predictions in the VHF and UHF bands

For decades now, a lot of radio wave path loss propagation models have been developed for predictions across different environmental terrains. Amongst these models, empirical models are practically the most popular due to their ease of application. However, their prediction accuracies are not as high as required. Therefore, extensive path loss measurement data are needed to develop novel measurement-oriented path loss models with suitable correction factors for varied frequency, capturing both local terrain and clutter information, this have been found to be relatively expensive. In this paper, a large-scale radio propagation path loss measurement campaign was conducted across the VHF and UHF frequencies. A multi-transmitter propagation set-up was employed to measure the strengths of radio signals from seven broadcasting transmitters (operating at 89.30, 103.5, 203.25, 479.25, 615.25, 559.25 and 695.25 MHz respectively) at various locations covering a distance of 145.5 km within Nigerian urban environments. The measurement procedure deployed ensured that the data obtained strictly reflect the shadowing effects on radio signal propagation by filtering out the small-scale fading components. The paper also, examines the feasibilities of applying Kriging method to predict distanced-based path losses in the VHF and UHF bands. This method was introduced to minimize the cost of measurements, analysis and predictions of path losses in built-up propagation environment

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods: We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings: Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation: Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding: Bill & Melinda Gates Foundation

Wavelet based MIMO-multicarrier system using forward error correction and beam forming

NoWavelet based multicarrier systems have attracted the attention of the researchers over the past few years to replace the conventional OFDM systems in the next generation communication systems. In this paper we have investigated the performance of such wavelet based systems using forward error correction with covolutional coding and interleaving in a Wavelet-SISO system and then in a Wavelet multicarrier modulation (WMCM) multiple input multiple output (MIMO) system using Convolutional coding and beamforming to reduce the source bit rate and overall system error and increase the data rate. Results show outstanding Bit Error Rate vs. Signal to Noise Ratio Performance. Other than better performance the proposed systems keep the computational burden off the receiver that has more cost and power constraints

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission. © 2019, The Author(s)

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission. © 2019, The Author(s)